Surgery Gene Testing Panel | Personalized Genetic Testing

SURGERY PANEL
Genetic Testing Prior To Surgery

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Personalized Genetic Testing provides the invaluable service of personalized genetic medicine testing to physicians and patients throughout the U.S.

Thousands of Tests Performed

Providing doctors with the information needed to determine the best medicines and treatments for each of their patients.

20+ Years Experience

Experience in biotechnology, pharmaceutical, hematology, flow cytometry, clinical molecular biology, immunology, and chemistry industries.

Fast 5-Day Turnaround

Using the latest technologies from the leaders in the industry, our process is 3 times faster than competitor’s analysis methods.

Accurate Reporting

Through Coriell Institute, backed by over 60 years of research experience providing the quality control required for validation in pharmacogenetics testing.

PGT’s genetic medication testing supports doctors in determining the appropriate medications and doses that are best suited for a patient’s genetic profile.

PGT Surgery Panel:

Worldwide it is projected that 234 million surgical procedures are carried out annually. It is supposed that 7 million patients experience impairment and 1 million dies each year post-operatively globally. It is also projected that up to 50% of this damage is preventable. CYP2D6 polymorphisms can impact the metabolism of some of these drugs (i.e. ondansetron and tropisetron) thereby affecting drug efficacy.

Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been used as an anesthetic for over 40 years. The drug has also been used in the managing of acute post-operative pain and chronic refractory pain, either solely or in combination with opioids. Although ketamine is said to produce some degree of analgesic and opioid-sparing effects in chronic pain patients. Ketamine is a high hepatic clearance drug. Variability in hepatic clearance may arise from its metabolism which is primarily to norketamine by two cytochrome P450 (CYP) enzymes, CYP2B6 and CYP3A4, whose expression and catalytic activities show large variability in humans. CYP3A5, if it is expressed, may also be involved in ketamine metabolism, since it has a catalytic specificity similar to CYP3A4.

OPIOIDS are at present the most useful analgesics, making them the drugs of choice for moderate to severe pain related to invasive procedures, cancer, and various other chronic disease states. Use Opioid agonists, such as morphine, hydromorphone, and oxymorphone, exert their analgesic properties via stimulation of the mu-1 opioid receptor. The μ-opioid receptor (OPRM1) A118G single nucleotide polymorphism has been the main attention of research into the pharmacogenetics of opioid response. The A118G allele variant of OPRM1 has the most potent influence on pain management of postoperative patients.

References:
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansetron and Tropisetron. 2016 Supplement.
Pharmacogenetics and anaesthetic drugs: Implications for perioperative practice Annals of Medicine and Surgery 4 ( 2015) 470e 474

PGT Surgery Panel can help define the appropriateness and dosage of many of these prescribed drugs including:
Therapeutic Class Name of Drug

Antidepressants

Imipramine (Tofranil®)
Vortioxetine (Brintellix ®)
Venlafaxine ( Effexor ®)
Protriptyline (Vivactil®)
Desipramine (Norpramin®)
Antipsychotics Quetiapine (Seroquel®)
Clozapine (Clorazil ®)
Opiates Codeine (Codeine®)
Buprenorphine (Subutex®)
Fentanyl (Duragesic®)
Hydrocodone (Vicodin®)
Morphine (Duramorph®)
Oxycodone (Oxycontin®)
Tramadol (Ultram®)
Anesthetics Ketamine (Ketalar®)
Propofol  (Diprivan®)
Local Anesthetics Lidocaine (Lidoderm®)
Ropivacaine (Naropin®)
Muscle Relaxants Carisoprodol (Soma®)
Nonsteroidal
Anti-inflammatory Drugs (NSAIDs)
Celecoxib (Celebrex®)
Diclofenac (Voltaren®)
Meloxicam (Mobic®)
Flurbiprofen
Selective Serotonin Reuptake Inhibitors (SSRIs) Citalopram / Escitalopram
Sertraline (Zoloft®)
Paroxetine (Paxil®)
Fluoxetine (Prozac®)
Statins Simvastatin (Zocor®)
Anticonvulsants Clobazam (Onfi®)
5-ht3 antagonist Ondansetron (Zofran®)